Abstract
The optimal prognosis for primary gastric lymphoma (PGL) is observed in those patients exhibiting PGL with minimal infiltration and who are eligible for radical resection. The initial treatment strategy for high-grade PGL (stages I/II) is chemotherapy followed by radiotherapy, however, subsequent to chemotherapy and/or radiotherapy for PGL, there is a risk of gastric bleeding and perforation. The present study reports two cases of PGL with refractory peptic ulcers that were negative for Helicobacter pylori following radiotherapy. Although the two patients received regular treatment for their ulcers and symptoms, the position and size of the ulcers remained unchanged for a number of years.
Highlights
Malignant lymphomas include Hodgkin's and non‐Hodgkin's lymphomas, which affect the stomach as either primary cancers or as part of a more widespread disease process
Chemotherapy followed by radiotherapy is the preferred initial treatment strategy for high‐grade stage I/II primary gastric lymphoma (PGL), as opposed to surgery, and chemotherapy alone is administered for advanced‐stage PGL cases [6,7]
Favorable outcomes resulting from various treatments make comparisons complex [8,9]
Summary
Malignant lymphomas include Hodgkin's and non‐Hodgkin's lymphomas, which affect the stomach as either primary cancers or as part of a more widespread disease process. The stomach is the most common site of secondary lymphoma [1,2]. Compared with other gastric cancers, primary gastric lymphoma (PGL) is increasingly common and accounts for 2‐8% of malignant gastric carcinomas [3,4,5]. Chemotherapy followed by radiotherapy is the preferred initial treatment strategy for high‐grade stage I/II PGL, as opposed to surgery, and chemotherapy alone is administered for advanced‐stage PGL cases [6,7]. The present study describes two cases of PGL with intractable peptic ulceration following radiotherapy
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