Abstract
Eleven patients with acute leukemia (acute lymphatic leukemia 8, acute myeloid leukemia 3) were treated with cytosine arabinoside and cyclophosphamide; two also received asparaginase and two others prednisone. Nine of them had refractory disease in which reinduction with vincristine and prednisone had failed; two others were unable to tolerate vincristine and so this drug was not used again. In 7 of the 11 patients (acute lymphatic leukemia 5, acute myeloid leukemia 2), a complete remission was readily achieved. We suggest that this combination therapy is effective and should be considered as an alternative to vincristine and prednisone when these drugs are no longer beneficial particularly in acute lymphatic leukemia.
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