Refractory Immune Checkpoint Inhibitor Colitis successfully managed with Tacrolimus

Abstract

Immune Checkpoint Inhibitor related colitis (“irColitis”) can range in severity from mild symptoms that may self resole with supportive therapy, to life-threatening disease. More severe cases require immunosuppression with corticosteroids or biologic therapies, but there is little evidence about what to do when these agents fail. In this article we present a case of irColitis that was refractory to established pharmacological treatments, but then resolved after introduction of Tacrolimus. Successful treatment of irColitis with Tacrolimus has not previously been reported and so this finding will be significant for future research studies and guidelines.