Abstract
多发性硬化( multiple sclerosis,MS)具有复发-缓解的慢性病程以及最初以炎症反应为主到后期以变性反应为主的疾病性质,治疗该病的新药要有充足的临床试验证据来评价.MS最佳的干预时机是其发病后早期,减轻炎症反应可减少复发并延缓功能障碍进展.近来研究热点是如何在变性反应为主的阶段改善残存神经功能.MS临床试验期通常为2～3年,在此期间如何观察到药物对MS病程的影响是临床试验预后指标研究的核心.充分理解应用并改良现有预后指标有助于更好评价治疗MS的新疗法。
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