Abstract
Journal of Paediatrics and Child HealthVolume 53, Issue S2 p. 19-19 AbstractsFree Access Refining anti-inflammatory therapy strategies for bronchopulmonary dysplasia First published: 20 April 2017 https://doi.org/10.1111/jpc.13494_47AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume53, IssueS2Special Issue: Abstracts of the 21st Annual Congress of the Perinatal Society of Australia and New Zealand (PSANZ), 2–5 April 2017, Canberra, AustraliaApril 2017Pages 19-19 RelatedInformation
Highlights
First described in 1967 [1], Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease affecting preterm infants
Having shown that interleukin-1 receptor antagonist (IL-1Ra) prevents the development of murine BPD [15], we set out to probe dosage and timing effects of IL-1Ra on BPD induced by perinatal inflammation and hyperoxia
We investigated whether an alternative anti-inflammatory agent, protein C (PC), has beneficial effects on BPD development
Summary
First described in 1967 [1], BPD is the most common chronic lung disease affecting preterm infants. BPD incidence exceeds 50% in the most premature infants before falling with increasing gestational age at birth [2]. As modern medicine is increasingly adept at keeping extremely preterm babies alive [3], BPD is on the rise. BPD used to be characterized by fibrosis resulting from ventilation-induced injury of the delicate lung tissue. With the introduction of gentle ventilation methods, antenatal steroids and surfactant-replacement therapy, the phenotype of BPD has changed dramatically. The ‘new BPD’ is characterized by arrested lung development involving reduced alveolarization and vascularization [4]. Affected children suffer from impaired neurodevelopment [5], respiratory dysfunction [6] and susceptibility to airway infections [7] that
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