Abstract
The Animal Study Registry (ASR; www.animalstudyregistry.org) was launched in January 2019 for preregistration of animal studies in order to increase transparency and reproducibility of bioscience research and to promote animal welfare. The registry is free of charge and is designed for exploratory and confirmatory studies within applied science as well as basic and preclinical research. The registration form helps scientists plan their study thoroughly by asking detailed questions concerning study design, methods, and statistics. With registration, the study automatically receives a digital object identifier (DOI) that marks it as intellectual property of the researcher. To accommodate the researchers concerns about theft of ideas, users can restrict the visibility of their registered studies for up to 5 years. The full content of the study becomes publicly accessible at the end of the embargo period. Because the platform is embedded in the infrastructure of the German Federal Government, continuity and data security are provided. By registering a study in the ASR, researchers can show their commitment to transparency and data quality to reviewers and editors, to third-party donors, and to the general public.
Highlights
The scientific community is striving for greater transparency in animal research as a measure to enhance the reproducibility of results and to gain more knowledge from animal studies.Missing efficacy was found to be the main reason for clinical failure of drug candidates [1,2,3,4], and irreproducibility of preclinical data was blamed to be the dominating cause
By registering a study in the Animal Study Registry (ASR), researchers can show their commitment to transparency and data quality to reviewers and editors, to third-party donors, and to the general public
The ASR registration process consists of four main steps: (1) entering the data, (2) submitting the study, (3) registration of the study, and (4) publication of the study (Fig 2)
Summary
Refining animal research: The Animal Study Registry a1111111111 a1111111111 a1111111111 a1111111111 a1111111111. Bettina BertID1☯*, Celine HeinlID1☯, Justyna Chmielewska1☯, Franziska Schwarz, Barbara GruneID1, Andreas Hensel, Matthias GreinerID2,3, Gilbert SchonfelderID1,4*
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