Abstract
Objective To screen the candidate tumor suppressor genes(TSGs)related to gastric cancer(GC)in 1 q43 region.Methods Four fluorescent labeled polymorphie markers were analvzed in the samples of GC and adjacent normal tissues obtained during operation performed on 96 GC patients,60 males and 36 females.The PCR products were eleetrophresed for loss of heterozygosity(LOH)scanning and analysis.Results The average LOH frequency in the 1 q43 region was 17.9%,with the highest LOH frequency of 26.5%at the D1S1594 locus,and lowest LOH frequency of 7.7%at DISl594 locus.There was no relationship between LOH frequency and cliniepathologcial data such aft the age and sex of the patients,the size and TNM stage of the tumor.Conclusion One high LOH region between D1 S1 594 and D1 S2785(1 q43,about 1 em)had been detected in GC,suggesting the existence of TSGs related to GC. Key words: Gastric carcinoma; LoSS of heterozygosity; Chromosome
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
