Abstract
20695 Background: The diagnosis of breast cancer in younger women and the need for systemic treatment has potential physical, psychological and social implications. The impact on fertility being one of these, this can have a profound effect on emotional well being and self-esteem. Given this problem appropriate referral and management within specialised fertility units with expertise in managing onco-fertility issues is necessary. Methods: Case notes of breast cancer patients referred to the Wolfson Family Clinic at Imperial Healthcare NHS trust, UK were reviewed. Results: 22 women were identified with a median age of 36 (range = 27–49). 21 women underwent ovarian stimulation. During ovarian stimulation the median day 2 FSH was 6.5 IU/L (range 2.5–11.58) with a median peak estradiol of 2066 pmol/L (range 240–10,057). The median number of collected oycytes was 5 (Range = 2–22). In 16 women oocytes were fertilised and embryos frozen, while 5 had oocytes frozen. 14 women had fertilisation done via intra-cytoplasmic sperm injection (ICSI) and 2 via in-vitro fertilisation (IVF). Where ICSI was utilised a median of 4 oocytes were injected (2–11), resulting in a median of 3 fertilised oocytes and embryos being frozen (range = 0–8). In IVF cases 9 and 12 oocytes were produced with 7 and 11 being fertilised respectively, all led to embryos which were frozen. In those women who underwent oocyte freezing alone a median of 15 oocytes (range 2–22) were collected and frozen. To date there have been 2 live births from 3 frozen embryo replacements. Method of ovarian stimulation, data on time to definitive systemic therapy from referral to fertility unit and outcome data will be presented. Conclusions: Fertility preservation is viable and successful prior to cytotoxic therapy for breast cancer and can lead to successful pregnancies. Work is required to investigate any potential detrimental effect on long term outcome. No significant financial relationships to disclose.
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