Abstract
Background. We have previously reported reference values for common clinical chemistry tests in healthy 70-year-old males and females. We have now repeated this study 5 years later to establish reference values also at the age of 75. It is important to have adequate reference values for elderly patients as biological markers may change over time, and adequate reference values are essential for correct clinical decisions.Methods. We have investigated 31 frequently used laboratory markers in 75-year-old males (n = 354) and females (n = 373) without diabetes. The 2.5 and 97.5 percentiles for these markers were calculated according to the recommendations of the International Federation of Clinical Chemistry.Results. Reference values are reported for 75-year-old males and females for 31 frequently used laboratory markers.Conclusion. There were minor differences between reference intervals calculated with and without individuals with cardiovascular diseases. Several of the reference intervals differed from Scandinavian reference intervals based on younger individuals (Nordic Reference Interval Project).
Highlights
During the last fifty years the number of routine laboratory tests has increased dramatically
While the test results are aimed at elderly patients, the reference intervals provided by the laboratory together with the test results are often based on younger individuals
The corresponding values obtained in the Nordic Reference Interval Project (NORIP) are presented
Summary
During the last fifty years the number of routine laboratory tests has increased dramatically. While the test results are aimed at elderly patients, the reference intervals provided by the laboratory together with the test results are often based on younger individuals. Publications often lack important information regarding reference population, methods used, traceability, and imprecision. Without such information it is difficult to transfer and use published reference values of other laboratories. We have previously reported reference values for common clinical chemistry tests in healthy 70-year-old males and females. It is important to have adequate reference values for elderly patients as biological markers may change over time, and adequate reference values are essential for correct clinical decisions. Reference values are reported for 75-year-old males and females for 31 frequently used laboratory markers. Several of the reference intervals differed from Scandinavian reference intervals based on younger individuals (Nordic Reference Interval Project)
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