Abstract
Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and biochemical reference intervals for healthy cynomolgus and rhesus monkeys anesthetized with ketamine hydrochloride. A total of 142 cynomolgus monkeys (28 males and 114 females) and 42 rhesus monkeys (22 males and 20 females) were selected and analyzed in order to examine reference intervals of 20 hematological and 16 biochemical parameters. The effects of sex were also investigated. Reference intervals for hematological and biochemical parameters were separately established by species (cynomolgus and rhesus) and sex (male and female). No sex-related differences were determined in erythrocyte-related parameters for cynomolgus and rhesus monkey housed in indoor laboratory conditions. Alkaline phosphatase and gamma glutamyltransferase were significantly lower in females than males in both cynomolgus and rhesus monkeys aged 48–96 months. The reference values for hematological and biochemical parameters established herein might provide valuable information for researchers using cynomolgus and rhesus monkeys in experimental conditions for biomedical studies.
Highlights
Non-human primates (NHPs) are valid and indispensable animal models for biomedical research because humans and NHPs are similar in behavior, physiology, and organ function
Previous report investigated that the alterations of hematological and serum biochemical values can be found in animals with ketamine anesthesia [12]
Despite the importance of non-human primates in biomedical research, only a few studies have examined the reference intervals of hematology and biochemistry for cynomolgus and rhesus macaques kept under laboratory conditions
Summary
Non-human primates (NHPs) are valid and indispensable animal models for biomedical research because humans and NHPs are similar in behavior, physiology, and organ function. Studies have shown (2019) 35:7 differences in blood hematology and biochemistry for laboratory cynomolgus and rhesus macaques according to origin, age, sex, and species [9,10,11]. Previous studies have reported that hematological and biochemical parameters can vary due to pre-analytical and environmental conditions [10, 12]. Despite the importance of non-human primates in biomedical research, only a few studies have examined the reference intervals of hematology and biochemistry for cynomolgus and rhesus macaques kept under laboratory conditions. The aim of this study was to provide comprehensive and accurate reference intervals of hematological and biochemical values for evaluating individual health condition indices of individually housed cynomolgus and rhesus macaques prior to their use in biomedical studies
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