Abstract
Background Left ventricular (LV) myocardial wall thickness is influenced by non-ischemic conditions like cardiomyopathies (CMP) as well as ischemic disorders, i. e. coronary artery disease (CAD). For CMP, regional wall thickness under resting conditions has prognostic value and serves as risk predictor for future cardiovascular events. In CAD, aside from perfusion also inadequate dobutamine wall thickening indicates myocardial ischemia and leads to coronary intervention. Therefore, quantitative resting and stress regional wall thickness provides relevant diagnostic and prognostic information. To date there is only scarce data regarding reference values of regional wall thickness in healthy volunteers. We sought to investigate differences in age and gender of LV rest and stress regional wall thickness with a state-of-the-art SSFP sequence in a modified AHA 17segment model and present reference values for myocardial rest and stress wall thickness.
Highlights
Left ventricular (LV) myocardial wall thickness is influenced by non-ischemic conditions like cardiomyopathies (CMP) as well as ischemic disorders, i. e. coronary artery disease (CAD)
The acquired normal values are shown in figure 1a and 1b. Both gender groups are similar in age (42.1±12.1 yrs vs. 41.8±13.3, p>0.9).The wall thickness of each segment differs significantly between men and women at rest as well as during stress
The discrepancies of the wall thickness between resting and Methods We studied 119 healthy volunteers in two gender groups (60 male, 56 female) which both consisted to equal parts of three age groups to minimize its possible influence. 30 of the male and 29 of the female participants were pharmacologically stressed with dobutamine up to their age-depended maximal heart rate according to present guidelines
Summary
Left ventricular (LV) myocardial wall thickness is influenced by non-ischemic conditions like cardiomyopathies (CMP) as well as ischemic disorders, i. e. coronary artery disease (CAD). Left ventricular (LV) myocardial wall thickness is influenced by non-ischemic conditions like cardiomyopathies (CMP) as well as ischemic disorders, i. For CMP, regional wall thickness under resting conditions has prognostic value and serves as risk predictor for future cardiovascular events. In CAD, aside from perfusion inadequate dobutamine wall thickening indicates myocardial ischemia and leads to coronary intervention. Quantitative resting and stress regional wall thickness provides relevant diagnostic and prognostic information. To date there is only scarce data regarding reference values of regional wall thickness in healthy volunteers. We sought to investigate differences in age and gender of LV rest and stress regional wall thickness with a state-of-the-art SSFP sequence in a modified AHA 17segment model and present reference values for myocardial rest and stress wall thickness
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