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Abstract
IntroductionSpecific TSH and free thyroxine ranges are needed to adequately assess maternal thyroid function during pregnancy. AimThe aim of this review is to review studies reporting data on references TSH and free thyroxine levels in Spanish women during the first trimester of pregnancy. Material and methodsLiterature search and selection of studies providing reference TSH ranges in the first trimester of pregnancy. ResultsThe TSH cut-off point to define hypothyroidism (P97.5) was different depending on the immunoassay used. Gestational age, thyroid autoimmunity, and maternal iodide nutritional status can determine the variability seen in the results. ConclusionsDifferences found in the studies do not allow for establishing a unified TSH reference range. However, results suggest that the TSH upper reference limit is close to 4μU/mL. Reference TSH ranges specific for each population and immunoassay during pregnancy should be defined.
Published Version
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