Abstract
BackgroundThe aim of the present study was to establish the normal ranges for foetal nasal bone length (NBL), prenasal skin thickness (PNT), interocular distance (IOD), and ratio of prenasal thickness to- nasal bone length (PNT/ NBL) at 18–24 weeks using two-dimensional (2D) ultrasound.MethodsThis study was a retrospective study of prenatal ultrasonographic records from 407 foetuses between 18 and 24 weeks gestational age (GA). The NBL, PNT, IOD, PNT/ NBL ratio, biparietal diameter (BPD), and femur length (FL) were investigated. The relationships among NBL, PNT, IOD, PNT/ NBL, and GA were evaluated. Additionally, descriptive statistics for NBL, PNT, and IOD values for each gestational week were obtained.ResultsThere was a significant association between GA and NBL, PNT, and IOD between 18 and 24 weeks. NBL increased from a mean of 5.5 mm to 8.3 mm, PNT increased from a mean of 3.5 mm to 5.1 mm, and IOD increased from a mean of 11.1 mm to 14.5 mm. PNT/NBL ratio did not change with gestational age.ConclusionsThis study showed normal ranges for NBL, PNT, IOD, and PNT/ NBL ratios for foetuses between 18 and 24 weeks in low-risk pregnancies. There was a positive linear relationship between GA and NBL, PNT, and IOD. The PNT/NBL ratio might be a more useful measurement than NBL or PNT alone.
Highlights
The aim of the present study was to establish the normal ranges for foetal nasal bone length (NBL), prenasal skin thickness (PNT), interocular distance (IOD), and ratio of prenasal thickness to- nasal bone length (PNT/ NBL) at 18–24 weeks using two-dimensional (2D) ultrasound
The percentile values were obtained for NBL, PNT, IOD and prenasal thickness and nasal bone length (PNT/NBL) ratio according to gestational week
PNT/NBL ratio did not change with gestational age (GA) (Table 2)
Summary
The aim of the present study was to establish the normal ranges for foetal nasal bone length (NBL), prenasal skin thickness (PNT), interocular distance (IOD), and ratio of prenasal thickness to- nasal bone length (PNT/ NBL) at 18–24 weeks using two-dimensional (2D) ultrasound. Down syndrome is defined by specific set of facial properties comprising a flat facial profile, a small nose, ocular hypotelorism, and an excessive amount of skin. This syndrome was first reported by Langdon Down in 1866 [1]. We aimed to obtain reference ranges for NBL, PNT, interocular distance (IOD), and the ratio between prenasal thickness and nasal bone length (PNT/NBL) in foetuses without known anomalies between 18 and 24 weeks’ gestation via two-dimensional (2D) ultrasound
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