Abstract
Objective To explore the reference range of exhaled nitric oxide (FeNO) for healthy adults in Jinan city,Shandong province,provide reference for the diagnose and treatment of chronic airway inflammation.Methods 200 healthy adults (non-smoking,no history of allergic diseases,no history of upper respiratory tract infection in the last two weeks,normal lung and heart function testing,normal serum IgE) in Jinan city were randomly selected.They were divided into five groups by age (A group:16-19 years old,B group:20-29 years old,C group:30-39 years old,D group:40-59 years old,and E group:60-80 years old).Each group had 20 men and 20 women.FeNO was measured at an exhalation flow rate of 50 ml/s with a rapid-response chemiluminescent analyzer (NIOX system,Aerocrine,Sweden)following ATS guidelines (2009).SPSS 18.0 for windows statistical package was used for statistical analysis.Results The data before and after grouping were non-normal distribution (P ＜0.05).FeNO of men was significantly higher than that of women (P ＜0.01),and there was no significant difference in FeNO among the five age groups (P ＞0.05).The 95％ reference range was determined by percentile method and the bilateral ranges were taken for data grouped by gender.The reference range of FeNO was 8-31 ppb for normal women and 9-39 ppb for normal men.Conclusions FeNO value of healthy men is higher than that of women in Jinan city,Shandong province.The difference should be considered in clincal application. Key words: Exhaled nitric oxide ; Reference range; Airway inflammation
Published Version
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