Reference intervals for whole blood viscosity using the analytical performance-evaluated scanning capillary tube viscometer

Abstract

ObjectivesThis study was performed to establish the reference intervals for whole blood viscosity (WBV) using the analytical performance-evaluated scanning capillary tube viscometer (SCTV). Design and methodsThe analytical performance of the SCTV was evaluated using three different levels of QC materials and sixty human EDTA-blood samples. To establish the reference intervals for WBV, 297 healthy individuals (123 men and 174 women) were selected from 1083 subjects. ResultsWithin-day precisions with QC materials and human whole blood and between-day precisions with QC materials were below 5.0%, 6.6% and 8.0% in CVs at all shear rates, respectively. Comparison tests between the SCTV and the Brookfield viscometer showed a significant correlation (R2=0.972, p<0.001). The reference intervals for WBV in healthy men were 3.66–5.41cP at 300s−1 and 23.15–36.45cP at 1s−1 while those in women were 3.27–4.32cP at 300s−1 and 18.20–27.36cP at 1s−1, respectively. ConclusionsUsing the analytical performance-evaluated SCTV, the reference intervals for WBV were established in healthy adults, which could be beneficial to the clinical utility of WBV in the aspect of appropriate modalities for the improvement of blood viscosity.