Reference Interval of Hemoglobin A1c and Influence of Hematological Parameters on Its Serum Concentration in Dogs.

Stephan Neumann

doi:10.1155/2020/7150901

Abstract

HbA1c could be an alternative to fructosamine as a marker for glucose levels over a longer period. In this study, we calculated a reference interval for HbA1c in dogs and investigated the correlation of HbA1c with hemoglobin and different hematological parameters. In total, 110 blood samples from dogs were investigated. Significant negative correlations were found between HbA1c and erythrocyte count, hemoglobin concentration, as well as hematocrit. There was a tendency in the red cell distribution width. No significant correlation was found in the reticulocyte number and the erythrocyte indices. In conclusion, there is an association of different blood parameters with the HbA1c concentration, which have to be considered for the interpretation of HbA1c.

Highlights

Diabetes mellitus is one of the most frequent endocrine diseases in dogs
Fructosamine gives an estimate of blood glucose concentration for the last 1–3 weeks because this is generally the half-life of albumin and other proteins that are bound with glucose [5, 6]
Blood samples were collected from healthy dogs (n 45) for routine examination or from nonhealthy dogs (n 65) including cases of diabetes mellitus (n 2) and anemia (n 10)

Summary

Introduction

Diabetes mellitus is one of the most frequent endocrine diseases in dogs. Various studies have assessed the prevalence of diabetes mellitus which ranges between 0.3 and 1.3%[1,2,3,4]. Diabetes mellitus is one of the most frequent endocrine diseases in dogs. Blood glucose levels can vary widely, and measurement of a second parameter, which gives more information about the glucose level over a long period, is recommended. Fructosamine gives an estimate of blood glucose concentration for the last 1–3 weeks because this is generally the half-life of albumin and other proteins that are bound with glucose [5, 6]. This parameter is commonly used in animals, whereas in humans, instead of fructosamine, hemoglobin

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