Reevaluation of the Acute Cystitis Symptom Score, a Self-Reporting Questionnaire. Part II. Patient-Reported Outcome Assessment.

Jakhongir F Alidjanov,Adrian Pilatz,Florian M Wagenlehner,Kurt G Naber,Ulugbek A Abdufattaev

doi:10.3390/antibiotics7020043

Abstract

This study aimed to reevaluate the Acute Cystitis Symptom Score (ACSS). The ACSS is a self-reporting questionnaire for the clinical diagnosis of acute uncomplicated cystitis (AC) and the assessment of symptomatic changes after therapy in female patients with AC. The part II of the present study was to reevaluate the utility of the different domains of the ACSS after therapy. The applicability of these domains in assessing changes in symptoms, as a function of time, in this population was investigated. The ACSS was evaluated in 48 female patients (mean age 31.1 ± 10.6) in the Uzbek and Russian languages, who returned after therapy and filled in part B of the ACSS, which corresponds to part A with the additional “Dynamics” domain. Descriptive statistics were used, where suitable. The reduction of typical symptoms and quality of life assessment between first and follow-up visit correlated significantly with answers in the “Dynamics” domain. Success/Cure and Non-success/Failure could be clearly differentiated by the scores obtained in “Typical” and “Quality of Life” domains. The ACSS has proven to be a useful instrument to clinically diagnose AC in women. It is also a suitable instrument for patient-reported outcome measures, with applicability both in daily practice and clinical studies. Slight modifications in the “Dynamics” domain will even increase the applicability.

Highlights

The Acute Cystitis Symptom Score (ACSS) was developed and validated as a simple and self-reporting questionnaire for diagnosing acute uncomplicated cystitis (AC) in female patients by assessing typical and differential symptoms, quality of life, and additional health conditions, which may play an important role in such a clinical setting
In the past the primary aim of clinical studies on female patients with uncomplicated acute cystitis (AC) was the eradication of bacteriuria at the test-of-cure visit and the clinical outcome was used as confirmation
≥10 leukocytes/mm3, and bacteriologic response was assessed as eradication (

Summary

Introduction

The Acute Cystitis Symptom Score (ACSS) was developed and validated as a simple and self-reporting questionnaire for diagnosing acute uncomplicated cystitis (AC) in female patients by assessing typical and differential symptoms, quality of life, and additional health conditions, which may play an important role in such a clinical setting. Uzbek and Russian languages, which included the results of the 58 women in whom the preliminary slightly different questionnaire: Urinary Symptoms and the Quality of Life Assessment. Part I of the report on the evaluation of the 228 women in whom only the current ACSS in Uzbek and Russian language was applied, deals mainly with the diagnostics of AC [3]. Antibiotics 2018, 7, 43 use (https://en.wikipedia.org/wiki/Uzbekistan), with the majority of the population speaking both languages. Both evaluations revealed significant differences in the scores in the domain with typical symptoms and with the quality of life between female patients with AC and controls. As an optimal threshold to predict AC, a total score of six points in the domain of typical symptoms can be established

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Conclusion