Reemergence of Recombinant Vaccine–derived Polioviruses in Healthy Children, Madagascar

Richter Razafindratsimandresy,Jean-Michel Heraud,Seta Andriamamonjy,Marie-Line Joffret,Francis Delpeyroux,Sendraharimanana Rabemanantsoa

doi:10.3201/eid1906.130080

Abstract

Reemergence of Recombinant Vaccine–derived Polioviruses in Healthy Children, Madagascar

Highlights

To the Editor: Poliomyelitis outbreaks caused by pathogenic vaccine-derived polioviruses (VDPVs) are primarily a result of low polio vaccine coverage
In June 2011, to determine if VDPVs were circulating in the province, we collected fecal samples from 616 healthy residents
Of the 616 samples, 238 induced cytopathogenic effects in human cells, of which 20 induced cytopathogenic effects in L20B cells; the latter samples were confirmed by reverse transcription PCR molecular testing (7) to contain PV strains

Summary

Introduction

To the Editor: Poliomyelitis outbreaks caused by pathogenic vaccine-derived polioviruses (VDPVs) are primarily a result of low polio vaccine coverage. No polio cases have been detected in Madagascar since 2005. In June 2011, to determine if VDPVs were circulating in the province, we collected fecal samples from 616 healthy residents

Results

Conclusion