Abstract
Acanthus ilicifolius L. is one of the mangrove plants that contain a lot of potential secondary metabolites of medicinal raw materials. People of Sambas Regency of West Kalimantan Province uses leaves extract daruju to overcome the pain in the stiff and swollen. The objective of this study was to know the antiinflammatory activity of leaves extract of daruju, in the form of edema reduction of mices feet induced carrageenan. The method used in the form of maceration and partition extraction followed by phytochemical test of crude extract and the fraction of result of partition. Furthermore, the crude extract and the fraction of the result of the partition were tested for the reduction of edema mices feet induced carrageenan. The results showed that ethyl acetate fraction had the best antiinflammatory activity because it was able to decrease the edema of mices feet by 75% at 750 mg / kg BW. Ethyl acetate fraction has the ability to reduce edema because it contains group compounds of flavonoid and terpenoid.
Highlights
Acanthus ilicifolius L. is one of the mangrove plants that contain a lot of potential secondary metabolites of medicinal raw materials
The results showed that ethyl acetate fraction had the best antiinflammatory activity because it was able to decrease the edema of mices feet by 75% at 750 mg / kg BW
F.H., Paulin, N., Elvis, C., Acha, A.E. 2008., Protective effect of Acanthus montanus in carrageenan-induced models of local inflammation , inhibitory effect on nitric oxide (NO) production, Pharmacologyonline 2, 161-169
Summary
Kalimantan Barat banyak menggunakan ekstrak daun daruju (Acanthus ilicifolius L.) untuk mengobati rasa nyeri pada kulit dan kaki yang bengkak. Oleh karena itu banyak sekali penelitian yang mulai mengeksplorasi aktivitas biologik ekstrak daun, akar dan batang dari genus Acanthus untuk mengetahui kandungan senyawa dan aktivitas farmakologinya. Ekstrak metanol seluruh gabungan bagian tanaman daruju menunjukkan aktivitas antikanker leher rahim terhadap sel HeLa. Namun belum ada informasi ilmiah tentang aktivitas antiinflamasi ekstrak daruju yang mereduksi udema kaki mencit setelah pemberian karagenan terutama untuk ekstrak daun daruju yang tumbuh di kawasan pantai dan sungai sekitar tanah gambut di Kalimantan Barat. Selanjutnya masing-masing ekstrak kental hasil partisi dilakukan skrining fitokimia dan uji reduksi udema kaki mencit yang diinduksi karagenan dengan alat plestimometer. Uji Fitokimia Ekstrak metanol dan fraksi-fraksi hasil partisi dilakukan skrining metabolit sekunder. Ekstrak kental metanol dan fraksi hasil partisi selanjutnya dilakukan skrining fitokimia untuk mengetahui kandungan metabolit sekundernya secara kualitatif (Tabel 1). Hasil Skrining Fitokimia Ekstrak Metanol dan Fraksi-Fraksi Hasil Partisi Daun Daruju
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