Reductions in Blood Pressures of Renal Hypertensive Dogs by Hog Renin.

Abstract

Conclusions1. Daily intramuscular injections of hog renin for 4 months produced striking reductions in the blood pressures of renal ischemic hypertensive dogs, whereas heat inactivated hog renin and active dog renin were without effect. 2. No toxic manifestations resulted from renin treatment or from the reductions in blood pressures. 3. The serums of the dogs treated with active hog renin neutralized the acute pressor effect of renin in assay animals. 4. The mechanism of these reductions in blood pressure is not clear. Most probably an immune (antihormone?) response to heterologous hog renin is involved.