Abstract
The influence of particle size and pressure on the column efficiency was investigated. The experimental results are explained by means of the theory of the theoretical plate height in chromatography. Columns of small diameter (0.75–1.5 mm) were prepared from porous solid supports of small particle diameters (down to 30 μm) which were coated with low liquid loadings (3–4% w/w) and operated at elevated pressure (inlet pressure up to 50 bar). As a result, a maximum of more than 10,000 theoretical plates per meter of column length were obtained for 30–35-μm particles at an inlet pressure of 25 bar at a mobile phase velocity of 2.5 cm/sec.
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