Abstract
The objective : to compare hemodynamic parameters, expiratory concentration of sevoflurane, fentanyl consumption during the surgery, the intensity of the pain syndrome during general combined anesthesia with and without dexmedetomidine. Subjects and methods : a prospective, blind, randomized study was performed in patients with oncogynecological disorders divided into two groups, where dexmedetomidine was used and not. Results . In the studied groups, changes in hemodynamics, expiratory concentration of sevoflurane, and fentanyl consumption were observed. There was no difference in the pain intensity between the groups. Conclusions . The expiratory concentration of sevoflurane, as well as the consumption of fentanyl, were lower in the group where dexmedetomidine was used. The intensity of the pain syndrome did not differ between two groups.
Highlights
REDUCTION OF SEVOFLURANE AND FENTANYL CONSUMPTION THROUGH DEXMEDETOMIDINE USE AS A PART OF GENERAL ANESTHESIA IN ONCOGYNECOLOGICAL SURGERY (A PROSPECTIVE BLIND RANDOMIZED STUDY)
Subjects and methods: a prospective, blind, randomized study was performed in patients with oncogynecological disorders divided into two groups, where dexmedetomidine was used and not
There was no difference in the pain intensity between the groups
Summary
В предоперационной устанавливали периферический венозный катетер, затем пациенткам группы 1 внутривенно вводили раствор NaCl 0,9%, пациенткам группы 2 ‒ дексмедетомидин из расчета 0,6 мкг/кг в течение 10 мин. После проведения индукции пациенткам группы 1 с помощью инфузомата вводили раствор NaCl 0,9%, пациенткам. В исследуемых группах сравнивали частоту гемодинамических изменений: неинвазивное среднее артериальное давление (САД) и частоту сердечных сокращений (ЧСС) исходные, через 10 мин, до и после индукции, после интубации, после разреза кожи и экстубации. Коррекцию показателей гемодинамики выполняли с помощью введения норадреналина при снижении САД более чем на 25% от исходного или снижение систолического артериального давления (АДсист) менее 90 мм рт. При этом если снижение ЧСС сопровождалось гемодинамической реакцией, вводили атропин в дозировке 0,01 мг/кг. Межгрупповые сравнения в отношении номинальных данных проводили с использованием χ2 Пирсона с поправкой Йейтса, а для количественных данных – U-теста Манна ‒ Уитни
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