Abstract
The effects of hyperthermia on rat thymocytes subjected to 1 kR irradiation were examined. Radiation-induced interphase death (judged by dye staining and ATP decline) observed after 4 hr of incubation of 37/sup 0/C following irradiation was reduced by exposing the cells for 30 min to 1 hr to 43/sup 0/C immediately before or after irradiation. Hyperthermia treatment at a lower temperature (such as 41/sup 0/C) was also effective in inducing cell recovery from radiation damage, although a longer treatment was needed. Hyperthermia administered 2 h after irradiation was ineffective and even enhanced cell death. To elucidate the mechanism underlying the effect, (/sup 14/C)adenine and (/sup 32/P)orthophosphate were used to estimate changes in ATP metabolism after heat exposure. Heat alone stimulated both ATP synthesis and degradation regardless of irradiation. Radiation-induced ATP degradation was markedly depressed by heat treatment.
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