Abstract
AbstractTo evaluate the efficiency of carboxymethylchitosan (CM‐chitosan)‐based hydrogels as barriers for reducing postsurgical adhesions, CM‐chitosan was synthesized to simplify the hydrogel‐making process, and the CM‐chitosan solutions were cross‐linked by using γ‐ray irradiation to create the desired hydrogels instead of using chemical cross‐linking reagents. The prepared CM‐chitosan hydrogels were characterized by a FTIR spectroscopy, swelling behavior, gel‐fraction content,and mechanical property such as gel strength of a hydrogel and the results showed a good swelling behavior and mechanical properties. Also, the radiation‐induced CM‐chitosan hydrogels significantly reduced and inhibited the postsurgical adhesions in the rat models. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
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