Abstract
Inclusion complexations of benoxaprofen (BXP) withβ-cyclodextrin (β-CyD) and heptakis (2,6-di-O-methyl)-β-CyD (DM-β-CyD) were studied by the solubility method and CD and1H-NMR spectroscopy. Both β-CyDs decelerated the photodecarboxylation of BXP, and suppressed the BXP-photosensitized hemolysis, where the inhibitory effect of DM-β-CyD was larger than that of β-CyD. This order was well correlated with the magnitude of the stability constants of BXP-β-CyD complexes. The peroxidation of lipid components in erythrocyte ghosts induced by BXP was also suppressed particularly by DM-β-CyD. The protective effect of β-CyDs on the BXP-induced photohemolysis seems to be due to the suppression in the photochemical reactions of BXP yielding toxic transient species, together with the inhibition in attacks of the transient species to the membrane, through inclusion complexation.
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