Abstract
Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis. Chondroitin sulfate and glucosamine are commonly used products for the symptomatic treatment of osteoarthritis. The aim of the present study was to investigate the effects of these products when used as structure-modifying drugs on the progression of osteoarthritis in the rabbit temporomandibular joint. Thirty-six New Zealand rabbits were divided into 3 groups (n = 12/group): control (no disease); osteoarthritis (disease induction); and treatment (disease induction and administration of chondroitin sulfate and glucosamine). Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate. Animals were killed at 30 and 90 days after initiation of therapy. The treatment was effective in reducing disease severity, with late effects and changes in the concentration of glycosaminoglycans in the articular disc. The results indicate that chondroitin sulfate and glucosamine may have a structure-modifying effect on the tissues of rabbit temporomandibular joints altered by osteoarthritis.
Highlights
Osteoarthritis (OA) is a severe joint disease that can affect the temporomandibular joint (TMJ), causing pain and functional limitations that compromise quality of life
Chondroitin sulfate (CS) and glucosamine (G) are commonly used as medicines or nutraceuticals to control the symptoms of OA, especially pain, stiffness, and decreased functional
The study was performed in accordance with Brazilian law no. 11794/2008, which establishes the guidelines for the care and use of laboratory animals, and was approved by the Ethics Committee for the Use of Animals in Research of Hospital de Clınicas de Porto Alegre (HCPA), approval no. 160238
Summary
Osteoarthritis (OA) is a severe joint disease that can affect the temporomandibular joint (TMJ), causing pain and functional limitations that compromise quality of life. The main pathologic features of temporomandibular joint osteoarthritis (TMJ-OA) are cartilage degeneration and subchondral bone sclerosis [1]. Optimal treatment involves altering the natural history of OA and reducing symptoms, inflammatory levels, and degenerative effects on cartilages and joint tissues [2]. Chondroitin sulfate (CS) and glucosamine (G) are commonly used as medicines or nutraceuticals to control the symptoms of OA, especially pain, stiffness, and decreased functional. Reduction of osteoarthritis severity in the temporomandibular joint of rabbits. Pathology Unit and Molecular Analyses and Proteins Unit of HCPA
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