Abstract
The angiotensin converting enzyme inhibitors (ACEIs) are a group of pharmaceuticals that are used primarily in treatment of hypertension and congestive heart failure, in some cases as the drugs of first choice. The renin-angiotensin system is activated in response to hypotension, decreased sodium concentration in the distal tubule, decreased blood volume and in renal sympathetic nerve stimulation. This study examines the effects of angiotensin converting enzyme inhibitor (Lisinopril) on blood pressure (BP) 131±2.4 and proteinuria 0.198±0.005 in Kurd hypertensive patients, mean arterial blood pressure and proteinuria excretion were measured weekly along the period of 12 weeks. Lisinopril significantly reduced mean arterial blood pressure, and attenuated proteinuria level in patients subjected to this study in lisinopril 10mg dose dependent manner (p<0.05, n=24). In conclusion, lisinopril is of beneficial of renoprotection and in lowering BP
Highlights
Elevated blood pressure and severe proteinuria are important predictions of progressive renal injury (Yano et al, 2012)
This study examines the effects of angiotensin converting enzyme inhibitor (Lisinopril) on blood pressure (BP) 131±2.4 and proteinuria 0.198±0.005 in Kurd hypertensive patients, mean arterial blood pressure and proteinuria excretion were measured weekly along the period of 12 weeks
While drugs which lower high blood pressure may all contribute to the preservation of kidney function, experiments in diabetic rats with hypertension have shown that the drugs which function by inhibiting angiotensin-converting enzyme are more effective in reducing proteinuria than other antihypertensive drugs (Windt et al, 2008)
Summary
Elevated blood pressure and severe proteinuria are important predictions of progressive renal injury (Yano et al, 2012). While drugs which lower high blood pressure (hypertension) may all contribute to the preservation of kidney function, experiments in diabetic rats with hypertension have shown that the drugs which function by inhibiting angiotensin-converting enzyme are more effective in reducing proteinuria than other antihypertensive drugs (Windt et al, 2008). There is clear evidence that pharmacologic blockade of the renin-angiotesnsin system (RAS) with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARB) reduces proteinuria and slows the progression of renal disease in diabetic and nondiabetic nephropathies, a beneficial effect that is not related to blood pressure control. The absence of response may be explained by the incomplete blockade of the RAS obtained with ACEI (Fernand-Juarez et al, 2006)
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