Abstract
S INCE 1963, we have been conducting a s tudy of var ious osmotherapeut ie agents, TM including hypertonic mannitol n and hyper tonic fructose. As a result of these studies, we have developed a new osmotherapeut ic agent, composed of 30% fructose and 15% manni to l in water. We have found this material , which we call Fruc ton-M,* the ideal agent for reducing increased intracranial pressure. This paper summarizes the studies which led to the deve lopment of F r u c t o n M and the clinical results wc have obtained using it.
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