Reduction of coagulability state one year after bariatric surgery

Abstract

BackgroundObese patients are in a hypercoagulable state relative to normal-weight patients. Low-grade inflammation may be a key factor for this condition. ObjectivesOur study aimed to compare the coagulability state of morbidly obese patients before and 1 year after bariatric surgery (BS) using the Thrombin Generation (TG) test, a validated method to assess coagulation in vitro. SettingUniversity hospital. MethodsAll patients undergoing BS between September 1, 2014 and April 30, 2015 were eligible for this prospective study (n = 42). Two distinct reagents were used for TG initiation based on the tissue factor concentration (Reagents LOW and HIGH). The main outcomes were endogenous thrombin potential (ETP) and peak height of TG. The rate of follow-up after one year was 97%. ResultsOne year after surgery, %weight loss was 32.5±8.4%; CRP decreased from 9.0 (3.7–12.9) to 1.1 (0.3–2.8) mg/mL (P<.001) and fibrinogen from 4.2±.8 to 3.5±.8 g/L (P<.001). The ETP (%) decreased from (108.0 (95.0–117.0) to 78.0 (71.0–98.0) (P<.001) (LOW reagent) and from 113.0 (103.0–134.0) to 96.0 (86.0–107.0) (P<.001) (HIGH reagent). Peak height (%) decreased from (117.0 (92.0–139.0) to 82.0 (70.0–111.0) (P = .003) (LOW reagent) and from 106.0 (96.0–118.0) to 97.0 (87.8–105.2) (P = .003) (HIGH reagent). ConclusionOur study shows a significant reduction in TG potential one year after BS in morbidly obese patients. Reduction of low grade inflammation may be one of the underlying mechanisms.