Abstract
The reduction of the carbonyl group of aldehydes and ketones to the corresponding alcohol is ubiquitous in organic synthesis. Since the first report of reduction by diborane more than half a century ago,1 metal hydride reagents have achieved preeminence as the reagents of choice for performing this synthetic transformation. The opportunities for variation in the metal, ligands, counterion and reaction conditions have enabled most problems of stereo-, regio- or chemo-selectivity in synthesis to be overcome satisfactorily. The majority of the complex metal hydrides described in this chapter that exhibit useful reducing properties are readily available from commercial sources, which has contributed enormously to their widespread acceptance and application.
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