Abstract
A preparative method for the synthesis of 9- (2,2,2-trifluoroethyl)-1,2,3,4,4a, 9a-hexahydro-γ-carbolines by the action of alkali metal borohydrides in trifluoroacetic acid on 1,2,3,4-tetrahydro-γ-carbolines was developed. The indicated trifluoroethyl derivatives can also be obtained by reaction of the same reagents with 1,2,3,4,4a,9a-hexahydro-γ-carbolines, which are intermediates in the overall reduction-trifluoroethylation process.
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