Abstract
The ability of apomorphine and other dopamine agonists to facilitate motor behaviour via dopamine receptors having a postsynaptic location has been acknowledged for many years. The more recent demonstration that low doses of apomorphine can reduce locomotor activity has also been interpreted in terms of an action on dopamine receptors. From the original study of Strombom (1975) arise 5 questions:1.Is the ability of apomorphine to reduce locomotor activity shared by other types of dopamine agonist?2.What are the characteristics of the ‘dopamine receptor’ mechanism(s) mediating the motor inhibitory effect?3.Which particular brain system(s) is relevant to the motor inhibitory effect?4.Has the receptor system(s) a pre- and/or postsynaptic location?5.Can the receptor mechanism(s) mediating a reduction in locomotor activity be differentiated from those mediating motor facilitation?
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