Abstract
Peripheral-blood T and B lymphocytes were measured in sixty-three patients with chronic alcoholism. Fourteen patients without clinical evidence of liver disease and seven with only fatty liver had normal proportions and numbers of circulating T cells. By contrast, T cells were significantly reduced in forty-two patients with alcoholic hepatitis and/or cirrhosis. The reduction was greatest in the group with alcoholic hepatitis. No consistent change in B cells was observed. The pronounced decrease in peripheral-blood T cells suggests that there is a basic impairment in cell-mediated immunity in alcoholic liver disease.
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