Abstract

The smooth muscle wall of the rabbit uterus is innervated by so-called short adrenergic neurons arising in peripherally located ganglia. Daily administration of estrogen for 2 weeks doubles the content of norepinephrine in the uterus, whereas the adrenergic transmitter level remains unchanged in the control organs (heart and ovaries) innervated by ordinary long adrenergic neurons. The increase persists even if the hormone treatment is interrupted after the first week. However, treatment with progesterone, with or without estrogen, during the second week restores the norepinephrine content of the uterus to a normal level. The results are discussed against the background of previously demonstrated marked changes in the adrenergic transmitter content of the uterus during pregnancy. (Endocrinology 84: 958, 1969)

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