Abstract
The organophosphate cholinesterase inhibitor soman (methyl pinacolylphosphufluoridate) produces potentiation of twitch tension in rat anterior tibial and phrenic nerve-diaphragm preparations by initiating repetitive electrical activity in the vicinity of the motor nerve terminals. Diazepam abolished this repetitive electrical activity and hence the associated potentiation of muscle twitch tension. These effects are produced by concentrations of iazepam that are without other apparent effects on neuromuscular transmission, as indicated by the absence of effect on normal twitch responses. The combination of diazepam with atropine provides additional protection against soman toxicity in rabbits.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
