Abstract
Abstract Saccharide-based nanoparticles with a synergistic effect on pH and reduction response licit a significant amount of attention because of their promising potential in controlled release for drug delivery. In this study, a chitooligosaccharide-based amphiphile, chitooligosaccharide-disulfide-polycaprolactone (COS-SS-PCL), is prepared with a dicarboxylic acid linker with a redox sensitive-disulfide bond and the amphiphile can self-assemble into nanoparticles through the solvent-induced method. The dual-sensitivity of the nanoparticles to pH change and reductive stimuli of glutathione (GSH) is investigated to achieve quick collapse of particles in an acidic and reductive environment. Furthermore, doxorubicin (DOX), as a drug model, is loaded copolymer particles are constructed. The release of DOX from nanoparticles in vitro is implemented under the concurrence of weak acid and GSH, and reveals the excellent synergistic effect on pH and GSH. Therefore, developing COS-SS-PCL as an effective pH and reduction dual-responsive carrier to enhance efficacy for drug delivery is promising.
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