Abstract
To compare the fibrillatory propensity of low concentrations of contrast media (140 mg I/ml) the ionic, ratio 1.5, contrast medium meglumine diatrizoate, the non-ionic, ratio 3, medium iopentol and equimolar glucose (0.37 mol/l) were perfused into 35 isolated rabbit hearts. The three substances were compared at three levels of sodium concentration (0, 77 and 154 mmol Na+/l). Meglumine diatrizoate without sodium caused the highest frequency of ventricular fibrillation (91 %). Iopentol without sodium caused a significantly lower frequency of ventricular fibrillation (17%). Glucose without sodium caused no fibrillation. The addition of 77 or 154 mmol Na+/l significantly decreased the frequency of ventricular fibrillation of both meglumine diatrizoate (3% and 6%) and iopentol (0%). Meglumine diatrizoate with sodium added caused a lower frequency of ventricular fibrillation than iopentol without sodium. At equal sodium concentrations (0, 77 and 154 mmol Na+/l) glucose caused smaller reduction in contractile fo...
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