Abstract
The past three decades have witnessed major gains in outcomes of patients with acute myocardial infarction owed largely to the implementation of systems of care prioritising timely reperfusion, advances in antithrombotic and antiplatelet therapies, and the development of post-myocardial infarction heart failure therapies.1–5 Preventative measures like smoking cessation, adoption of healthy aerobic lifestyles, and intensified treatment of risk factors including hypertension, diabetes, and hypercholesterolaemia have further contributed to reducing the burden of atherosclerotic coronary artery disease and decreased the incidence of age-adjusted myocardial infarction.
Highlights
Preventative measures like smoking cessation, adoption of healthy aerobic lifestyles, and intensified treatment of risk factors including hypertension, diabetes, and hypercholesterolaemia have further contributed to reducing the burden of atherosclerotic coronary artery disease and decreased the incidence of age-adjusted myocardial infarction
Central to guiding providers and public health policies in the pursuit of this progress is an understanding of the relative contributions of myocardial infarction event and case fatality rates to these secular trends in myocardial infarction mortality burden
In one of the largest samples of any study of acute myocardial infarction to date, the authors analyse contemporary trends in event and case fatality rates for myocardial infarction across four jurisdictions with national healthcare systems from 2002–15.6 This large sample size provides perhaps the most accurate estimation of event and case fatality rates of myocardial infarction to date, and allows for granularity when examining differences between demographic subgroups, which is often lacking from other studies
Summary
The past three decades have witnessed major gains in outcomes of patients with acute myocardial infarction owed largely to the implementation of systems of care prioritising timely reperfusion, advances in antithrombotic and antiplatelet therapies, and the development of post-myocardial infarction heart failure therapies.[1–5] Preventative measures like smoking cessation, adoption of healthy aerobic lifestyles, and intensified treatment of risk factors including hypertension, diabetes, and hypercholesterolaemia have further contributed to reducing the burden of atherosclerotic coronary artery disease and decreased the incidence of age-adjusted myocardial infarction. Central to guiding providers and public health policies in the pursuit of this progress is an understanding of the relative contributions of myocardial infarction event and case fatality rates to these secular trends in myocardial infarction mortality burden.
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