Reducing the Foreign Body Reaction by Surface Modification with Collagen/Hyaluronic Acid Multilayered Films

Cindy Yi Chi Hsieh,Wei-Bor Tsai,Wen-Shiang Chen,Fang-Wei Hu

doi:10.1155/2014/718432

Cindy Yi Chi Hsieh, Wei-Bor Tsai + Show 2 more

Open Access

https://doi.org/10.1155/2014/718432

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Abstract

Biological response against foreign implants often leads to encapsulation, possibly resulting in malfunction of implants devices. The aim of this study was to reduce the foreign body reaction by surface modification of biomaterials through layer-by-layer deposition of type I collagen (COL)/hyaluronic acid (HA) multilayer films. Polydimethylsiloxane (PDMS) samples were coated with alternative COL and HA layers with different layers. We found that the in vitro adhesion, proliferation, and activation of macrophage-like cells were greatly decreased by COL/HA multilayered deposition. The PDMS samples modified with 20 bilayers of COL/HA were implanted in rats for 3 weeks, and the thickness of encapsulation surrounding the samples was decreased by 29–57% compared to the control unmodified PDMS. This study demonstrates the potential of COL/HA multilayer films to reduce foreign body reaction.

Highlights

Biological response against artificial implants leads to encapsulation of implants, which often causes malfunction of implants or patients’ agonies due to capsular contracture [1,2,3]
The aim of the current study was to evaluate the modification of COL/hyaluronic acid (HA) on a polydimethylsiloxane (PDMS), a silicone that is widely used in breast implants, for reducing the foreign body reaction
quartz crystal microbalance (QCM) measurement was applied to investigate the development of COL/HA multilayered films in this study

Summary

Introduction

Biological response against artificial implants leads to encapsulation of implants, which often causes malfunction of implants or patients’ agonies due to capsular contracture [1,2,3]. When a foreign material is implanted into a host, the interaction between the material and the surrounding injured tissues causes acute inflammation, similar to the natural healing process that usually lasts for a week [1, 2]. Chronic inflammation with the participation of monocytes, macrophages, and foreign body giant cells (FBGCs) may occur with a duration of less than 3 weeks if the wound is not healed [1]. The inability of FGBCs in eliminating the foreign object will lead to a route to encapsulation of the implant with dense collagen matrix that is secreted by fibroblasts in order to wall the foreign object off the host [1, 2]

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