Abstract

There is growing interest in the role of sedentary behavior as a risk factor for poor health, independent of physical activity (PA). To guide the spectrum of descriptive, analytic, and intervention studies on sedentary behavior, the authors advocate a behavioral epidemiology framework. This 5-phase framework is useful because it outlines a series of sequential stages important for developing, evaluating, and diffusing interventions to reduce sedentary behavior and improve population health. Studies of sedentary behavior and health outcomes (phase I) have found consistent evidence that excessive use of screen-based media is linked to overweight and obesity in children, and there is some evidence among adults that overall sedentary time is associated with risk factors for cardiometabolic disease, some cancers, and mortality. Biological mechanisms to explain possible relationships have started to emerge but are mostly based on animal models. Obtaining valid and reliable measurements of sedentary behavior (phase II) remains a research priority because self-reports are prone to recall bias, and it appears that sedentary habits do not appear to be well represented by measures of individual behaviors such as TV viewing. Studies have identified few modifiable correlates of sedentary behavior (phase III), although research appears to be limited to studies of TV viewing or to scenarios in which sedentary behavior is defined as an absence of PA. Rigorous intervention research (phase IV) has focused almost exclusively on reducing self-reported TV viewing among children and adolescents, and there is consistent evidence that these interventions are efficacious. There appear to be no interventions focused exclusively on reducing sedentary behavior of adults. Translation studies (phase V) are absent because the underlying evidence is still emerging. Future research should focus on examining causal associations between sedentary behavior and health, developing objective measures of domain-specific sitting time, and identifying modifiable correlates of sedentary behavior that can be used as leverage points for behavioral interventions.

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