Abstract
A study demonstrated the reducing of protein corona (PC) formation and enhancing colloidal stability of gold nanoparticles (Au NP) by capping with silica monolayers. Au NP surface was needed to achieve silica monolayer formation. In a first attempt to have a high density ligand coverage around NS-1, an excess of 3-mercaptopropyltrimethoxysilane (MPTMS) was directly added to a Au NP hydrosol, but this resulted in immediate aggregation. The resulting trimethoxysilane moiety covering the surface of NS-3 was subsequently hydrolyzed by addition of 5 mM NaOH in a 2:1 methanol/water mixture, yielding a polymeric monolayer.
Highlights
Is a commercially available molecule, which is often employed to functionalize silica surfaces with thiol groups,[18] or as a primer for the deposition of silica shells on metal nanoparticles.[19]
It has been described that, when a metallic surface containing a high density of MPTMS is treated with an aqueous basic solution, the silane groups can cross-link through the formation of siloxane bonds, thereby forming a polymeric silica monolayer over the metallic surface.[20,21]
We envisioned the implementation of a similar process toward stabilizing Au NPs via the formation of a silica monolayer, which would be connected to the NP surface by a large number of thiol-metal bonds, resulting in Au NPs with high colloidal and chemical stability.[22,23]
Summary
Is a commercially available molecule, which is often employed to functionalize silica surfaces with thiol groups,[18] or as a primer for the deposition of silica shells on metal nanoparticles.[19]. NPs include capping with thiolated organic polymers and coating with silica shells.[10,11] The former method takes advantage of the high affinity between gold and thiols, to attach polymers that enhance colloidal stability in aqueous media, such as thiolated PEG.
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