Abstract
Introduction: Calcineurin inhibitors (CNI) therapy is associated with a 20% incidence of chronic renal failure in both adult and pediatric liver transplant recipients. The degree of renal impairment present also directly correlates with risk of cardiovascular mortality in transplant recipients. In spite of the fact that pediatric transplant recipients typically have a longer projected lifetime than adult liver transplant recipients, few studies have compared the renal function of pediatric liver transplant recipients receiving different two different immunosuppression regimens to determine if reduced doses of calcineurin inhibitor therapy would minimize nephrotoxicity.
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