Abstract
Oxidative stress is the consequence of an imbalance between pro-oxidant and antioxidant processes. Antioxidants that counteract reactive oxygen species do not all work the same way. Both resveratrol and the more powerful 4-hydroxytyrosol are excellent reducing agents. Polyphenol treatment (red wine polyphenols, resveratrol and catechin) is associated with a significant increase in anion permeability for chloride compared with control and 2.2′-azobis-2 amidinopropan dihydrochloride affected cells. Treatment with polyphenols was associated with a significant reduction in mean ± standard error of the mean membrane lipid peroxidation compared with control and 2.2′-azobis-2 amidinopropan dihydrochloride treatment. Hemolysis data are also obtained in the previously described conditions. 4-hydroxytyrosol is shown to significantly protect red blood cells from oxidative damage by 4-hydroxynonenal. But there are paradoxical effects like uric acid and creatinine. The obtained data evidence that both creatinine and uric acid levels have influence on the ratio of both malondialdehyde/protein and 4-hydroxynonenal/protein content on red blood cell ghosts, demonstrating their possible protective role against oxidative stress at low concentrations in blood and oxidizing power at higher concentrations. Finally, polyunsaturated fatty acids do not have all this reducing power.
Highlights
IntroductionChemical stress induced by the presence, in a living organism, of an excess of reactive chemical species, generally centered on oxygen (reactive oxygen species), secondary to an increased production of the same and / or to a reduced efficiency of the physiological systems of antioxidant defense
Chemical stress induced by the presence, in a living organism, of an excess of reactive chemical species, generally centered on oxygen, secondary to an increased production of the same and / or to a reduced efficiency of the physiological systems of antioxidant defense
The accumulation of the alkenals in Red Blood Cell (RBC) membrane could be produced either by partial Polyunsaturated fatty acids (PUFAs) oxidation contained in glycerides and plasma glycerides and by glycerides into recycled plasma membrane in RBC neogenesis (Figure 10)
Summary
Chemical stress induced by the presence, in a living organism, of an excess of reactive chemical species, generally centered on oxygen (reactive oxygen species), secondary to an increased production of the same and / or to a reduced efficiency of the physiological systems of antioxidant defense. Creatinine can function as a blood antioxidant, protecting cells from oxidative damage, genotoxicity and can potentially increase their lifespan While one explanation for this paradox could be that a rise in uric acid concentration represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell) We suggest that it is the pro-oxidative effect of uric acid, that occurs in cardiovascular disease and may have a contributory role in the pathogenesis of this condition. After 180 d of treatment, to baseline values and AAPH-induced lipid peroxidation increased in a dose-dependent manner These results show that high doses of dietary n-3 PUFAs, as well as long-time treatments, affect human RBC susceptibility to lipid peroxidation by changes in fatty acid composition content [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
