Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy

Abstract

I read the article by Yamashita and associates with interest. The article described advantages of reduced-fluence photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV).1 I would like to comment about the application of PDT in PCV. PDT is associated with several disadvantages. First, PCV often presents as multiple widely distributed lesions, so it may be difficult to treat all lesions, including multiple polyps and interconnecting vessels, with a single beam of PDT. Treatment of leaking polypoidal dilations only, without treating the entire vascular complex, can result in persistence or worsening of exudation.