Abstract
This study evaluated urinary angiotensinogen in preeclampsia. Normal pregnant (n=57) and preeclamptic patients (n=31); Normal pregnant (n=10) and preeclamptic rats (n=10) were studied. Urinary angiotensinogen and plasma angiotensin II were assayed by enzyme-linked immunosorbent assay (ELISA). Urinary angiotensinogen in preeclampsia patients (2.0±1.1ng/mg creatinine) was suppressed (*p<0.05) compared to normal pregnant (2.7±1.5ng/mg creatinine). Plasma angiotensin II in preeclampsia patients (preeclampsia: 36.2±7; normal pregnant: 48.1±5fmol/mL) was lower. The similar result was observed in preeclampsia rat model. The reduced urinary excretion of angiotensinogen was both in human preeclampsia patients and rat model of preeclampsia.
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