Reduced Th22 Cell Proportion and Prevention of Atopic Dermatitis in Infants Following Maternal Probiotic Supplementation

Abstract

ADB Ro, MR Simpson, TB Ro. Clin Exp Allergy. 2017;47(8):1014–1021 To examine whether T helper (Th) cell proportions were affected by maternal probiotic supplementation and whether the preventive effect of probiotics on atopic dermatitis (AD) was mediated through an effect on Th cells. The study included 415 pregnant women recruited from the double-blinded, randomized, placebo-controlled Probiotics in the Prevention of Allergy among Children in Trondheim study. Study subjects were randomly assigned to ingest probiotic milk corresponding to a daily dose of 5 × 1010 colony-forming units (CFUs) of Lactobacillus rhamnosus GG, 5 × 1010 CFUs of …