Year-end Sale % OFF 
Abstract
BackgroundVGF (nonacronymic) is a neuropeptide that plays an important role in the pathogenesis of major depressive disorder (MDD). However, no studies have yet investigated VGF levels in patients with MDD who are at risk of suicide. The purpose of the present study was to determine whether serum VGF levels are related to suicide risk in patients with MMD.MethodsA total of 107 patients with MDD and 40 normal control participated in the present study. The risk of suicide was assessed using the Nurses Global Assessment of Suicide Risk (NGASR). On this basis, 60 patients were assigned to a high-risk group (NGASR≥9) and 47 were assigned to a low-risk group (NGASR< 9). The severity of depression was measured using the 17-item Hamilton Depression Rating Scale (HDRS). Levels of serum VGF were determined using a double antibody sandwich enzyme-linked immunosorbent assay.ResultsSerum VGF levels in the high-risk group (883.34 ± 139.67 pg/mL) were significantly lower than in the low-risk group (1020.56 ± 131.76 pg/mL) and in the control group (1107.00 ± 155.38 pg/mL) (F = 31.90, p < 0.001). In patients with MDD, suicide risk was significantly negatively correlated with VGF levels (r = − 0.55, p = 0.001).ConclusionsReduced serum VGF levels are related to risk of suicide in patients with MDD, so VGF may be a biomarker of suicide risk in MDD.
Highlights
VGF is a neuropeptide that plays an important role in the pathogenesis of major depressive disorder (MDD)
It has been found that prolactin, thyroid hormone, catecholamine, arginine vasopressin, adrenocorticotropin and cortisol are all proposed to be suicide risk in patients with depression levels are associated with suicide attempts in patients with a history of suicidal behavior [16, 17]
The aim of the present study was to explore whether serum VGF levels were linked to risk of suicide, and to determine whether VGF could be used as a biomarker for predicting the risk of suicide in patients with MDD
Summary
VGF (nonacronymic) is a neuropeptide that plays an important role in the pathogenesis of major depressive disorder (MDD). No studies have yet investigated VGF levels in patients with MDD who are at risk of suicide. Recent study provide growing evidence that brain-derived neurotrophic factor (BDNF), the most abundant eurotrophin in the brain and plasma, is related to suicidal behaviorin MDD and that BDNF level may be a biological marker of suicidal depression [18].
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
