Abstract
BackgroundPrevious studies have shown a lower incidence of stroke in Parkinson’s disease (PD) patients. The role of the lipids and lipoproteins as risk factors for stroke is uncertain in the lower prevalence of stroke in PD patients.ObjectivesTo explore the lipids and lipoproteins serum levels in PD patients.MethodsA retrospective study was performed on 110 PD patients (PD group), 130 controls with non-cerebrovascular neurological diseases (OD group), 140 acute intracerebral hemorrhage patients (ICH group) and 140 acute cerebral infarction patients (CI group). The records about serum levels of lipids and lipoproteins were analyzed.ResultsThere were significant differences for the serum level of triglyceride (F = 5.031, p=0.002), very low density lipoprotein cholesterol (F = 5.313, p=0.001), apolipoprotein B (F = 16.038, p<0.0001) in the four groups. PD group had a significantly lower serum level of triglyceride (TG) than the OD (p=0.032), ICH (p=0.00047) and CI (p=0.001) groups. Very low density lipoprotein cholesterol (VLDL-C) serum level was significantly lower in PD group than in OD (p=0.039), ICH (p=0.00021) and CI (p=0.001) groups. There was a significantly lower serum level of apolipoprotein B (apo B) in PD group than in OD (p=0.002), ICH (p<0.0001) and CI (p<0.0001) groups.ConclusionsThere are reduced serum levels of TG, VLDL-C and apo B in PD patients, which may be related to the decreased prevalence of stroke in PD patients.
Highlights
Parkinson’s disease (PD) is an age-related disorder that classically presents with extrapyramidal symptoms of tremor, rigidity, bradykinesia and postural instability, and includes nonmotor symptoms such as depression, anxiety, muscular pain and other disturbances
The occurrence of PD is due to the neuronal degeneration of substantia nigra pars compacta, which causes the deficiency of dopaminergic neurotransmission in the basal ganglia [1,2]
We find that the serum levels of TG, Very low density lipoprotein cholesterol (VLDL-C) and apolipoprotein B (apo B) are the most remarkable indexes that are significantly lower in PD group than in OD, CI and ICH groups
Summary
Parkinson’s disease (PD) is an age-related disorder that classically presents with extrapyramidal symptoms of tremor, rigidity, bradykinesia and postural instability, and includes nonmotor symptoms such as depression, anxiety, muscular pain and other disturbances. Not confirmed by some authors [3], epidemiological studies seem to show a reduced incidence of stroke in PD patients. Previous studies have shown a lower incidence of stroke in Parkinson’s disease (PD) patients. PD group had a significantly lower serum level of triglyceride (TG) than the OD (p=0.032), ICH (p=0.00047) and CI (p=0.001) groups. Very low density lipoprotein cholesterol (VLDL-C) serum level was significantly lower in PD group than in OD (p=0.039), ICH (p=0.00021) and CI (p=0.001) groups. There was a significantly lower serum level of apolipoprotein B (apo B) in PD group than in OD (p=0.002), ICH (p
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