Abstract
Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.British Journal of Cancer (2002) 87, 28–30. doi:10.1038/sj.bjc.6600362 www.bjcancer.com© 2002 Cancer Research UK
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