Abstract
Address: 1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, , USA, 2Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA, 3Department of Cardiology, Johns Hopkins University School of Medicine, Baltimore, USA, 4Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, USA and 5Department of Pulmonology, Johns Hopkins University School of Medicine, Baltimore, USA * Corresponding author
Highlights
In patients with pulmonary arterial hypertension (PAH), the right ventricle (RV) undergoes hypertrophy and remodeling, eventually leading to RV failure and death
Twenty-five patients (59.6 years, 52.8-66.6, 22 females) who were referred for known or suspected PAH underwent adenosine stress cardiac MRI and right heart catheterization (RHC) on the same day. They were subdivided into groups with PAH and without PAH
Biventricular global myocardial blood flow (MBF) was calculated by MBF mapping, using the Fermi function model (Figure 1)
Summary
In patients with pulmonary arterial hypertension (PAH), the right ventricle (RV) undergoes hypertrophy and remodeling, eventually leading to RV failure and death. Patients with left ventricular (LV) failure are known to have reduced myocardial blood flow (MBF). The relationship of LV and RV myocardial perfusion reserve (MPR) in patients with PAH remains unclear. To evaluate biventricular perfusion at rest and under adenosine stress in patients with known or suspected PAH in relation to biventricular function and pulmonary hemodynamic parameters
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